解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Intermittent hypobaric hypoxia (IH) is linked with oxidative stress, impairing cardiac function. However, early IH also activate cardio-protective mechanisms. Omega 3 fatty acids (Ω3) induce cardioprotection by reducing infarct size and reinforcing antioxidant defenses. The aim of this work was to determine the combin...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13020838
更新日期:2015-02-04 00:00:00
abstract::Natural anionic polysaccharides fucosylated chondroitin sulfates (FCS) from sea cucumbers attract great attention nowadays due to their ability to influence various biological processes, such as blood coagulation, thrombosis, angiogenesis, inflammation, bacterial and viral adhesion. To determine pharmacophore fragment...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13020770
更新日期:2015-02-02 00:00:00
abstract::This work describes the synthesis and biological evaluation of a new heterocyclic hybrid derived from the ellipticine and the marine alkaloid makaluvamine A. Pyridoquinoxalinedione 12 was obtained in seven steps with 6.5% overall yield. 12 and its intermediates 1-11 were evaluated for their in vitro cytotoxic activity...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13010655
更新日期:2015-01-19 00:00:00
abstract::Sea cucumbers produce numerous compounds with a wide range of chemical structural diversity. Among these, saponins are the most diverse and include sulfated, non-sulfated, acetylated and methylated congeners with different aglycone and sugar moieties. In this study, MALDI and ESI tandem mass spectrometry, in the posit...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13010597
更新日期:2015-01-16 00:00:00
abstract::Magnetotactic bacteria (MTB) produce intracellular organelles called magnetosomes which are magnetic nanoparticles composed of magnetite (Fe3O4) or greigite (Fe3S4) enveloped by a lipid bilayer. The synthesis of a magnetosome is through a genetically controlled process in which the bacterium has control over the compo...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md13010389
更新日期:2015-01-16 00:00:00
abstract:BACKGROUND:Evaluation of the potential efficacy and safety of combination therapies for advanced soft tissue sarcomas (STS) has increased substantially after approval of trabectedin and pazopanib. Trabectedin's introduction in Europe in 2007 depended mainly on its activity in so-called L-sarcomas (liposarcoma and leiom...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13010379
更新日期:2015-01-13 00:00:00
abstract::Five new sulfide diketopiperazine derivatives, namely, penicibrocazines A-E (1-5), along with a known congener (6), were isolated and identified from the culture extract of Penicillium brocae MA-231, an endophytic fungus obtained from the fresh tissue of the marine mangrove plant Avicennia marina. The structures of th...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13010276
更新日期:2015-01-07 00:00:00
abstract::A bioassay guided fractionation of the ethyl acetate extract from culture broths of the strain Streptomyces zhaozhouensis CA-185989 led to the isolation of three new polycyclic tetramic acid macrolactams (1-3) and four known compounds. All the new compounds were structurally related to the known Streptomyces metabolit...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13010128
更新日期:2014-12-29 00:00:00
abstract::Long chain polyunsaturated fatty acids (LC-PUFAs) are important mediators in improving and maintaining human health over the total lifespan. One topic we especially focus on in this review is omega-3 LC-PUFA docosahexaenoic acid (DHA). Adequate DHA levels are essential during neurodevelopment and, in addition, benefic...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md12126190
更新日期:2014-12-18 00:00:00
abstract::A novel sesquiterpenoid, rumphellaoic acid A (1), was isolated from the gorgonian coral Rumphella antipathies, and was found to possess a carbon skeleton that was obtained for the first time from a natural sources. The structure of 1 was elucidated by spectroscopic methods and this compound and was found to exert a mo...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12125856
更新日期:2014-12-04 00:00:00
abstract::The aim of this research was to prepare and characterize alginate-chitosan mucoadhesive microparticles containing puerarin. The microparticles were prepared by an emulsification-internal gelatin method using a combination of chitosan and Ca2+ as cationic components and alginate as anions. Surface morphology, particle ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12125764
更新日期:2014-12-01 00:00:00
abstract::Chitosan is the N-deacetylated derivative of chitin, a naturally abundant mucopolysaccharide that consists of 2-acetamido-2-deoxy-β-d-glucose through a β (1→4) linkage and is found in nature as the supporting material of crustaceans, insects, etc. Chitosan has been strongly recommended as a suitable functional materia...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md12115619
更新日期:2014-11-24 00:00:00
abstract::In our search for quorum-sensing (QS) disrupting molecules, 75 fungal isolates were recovered from reef organisms (endophytes), saline lakes and mangrove rhizosphere. Their QS inhibitory activity was evaluated in Chromobacterium violaceum CVO26. Four strains of endophytic fungi stood out for their potent activity at c...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12115503
更新日期:2014-11-19 00:00:00
abstract::Eight new compounds, sinulolides A-H (1-8), along with two known compounds, α-methoxy-2,3-dimethyl-butenolide (9) and sinularone D (10), were isolated from the soft coral Sinularia sp. The structures of these compounds were elucidated on the basis of extensive spectroscopic analysis. The absolute configurations were d...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12105316
更新日期:2014-10-23 00:00:00
abstract::Global incidence of type 2 diabetes has escalated over the past few decades, necessitating a continued search for natural sources of enzyme inhibitors to offset postprandial hyperglycemia. The objective of this study was to evaluate coastal Alaskan seaweed inhibition of α-glucosidase and α-amylase, two carbolytic enzy...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12105277
更新日期:2014-10-22 00:00:00
abstract::TNF-related apoptosis-inducing ligand (TRAIL) is a tumor-selective apoptosis inducer and has been shown to be promising for treating various types of cancers. However, the application of TRAIL is greatly impeded by the resistance of cancer cells to its action. Studies show that overexpression of some critical pro-surv...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12095072
更新日期:2014-09-25 00:00:00
abstract::Collagen has become a key-molecule in cell culture studies and in the tissue engineering field. Industrially, the principal sources of collagen are calf skin and bones which, however, could be associated to risks of serious disease transmission. In fact, collagen derived from alternative and riskless sources is requir...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12094912
更新日期:2014-09-24 00:00:00
abstract::Marine sponges belonging to the phylum Porifera (Metazoa), evolutionarily the oldest animals are the single best source of marine natural products. The present review presents a comprehensive overview of the source, taxonomy, country of origin or geographical position, chemical class, and biological activity of sponge...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md12084539
更新日期:2014-08-19 00:00:00
abstract::In this study, we developed novel chitosan/fucoidan nanoparticles (CS/F NPs) using a simple polyelectrolyte self-assembly method and evaluated their potential to be antioxidant carriers. As the CS/F weight ratio was 5/1, the CS/F NPs were spherical and exhibited diameters of approximately 230-250 nm, as demonstrated b...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12084379
更新日期:2014-07-31 00:00:00
abstract::A series of novel marinopyrroles with sulfide and sulphone spacers were designed and synthesized. Their activity to disrupt the binding of the pro-apoptotic protein, Bim, to the pro-survival proteins, Mcl-1 and Bcl-xL, was evaluated using ELISA assays. Fluorescence-quenching (FQ) assays confirmed the direct binding of...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12084311
更新日期:2014-07-29 00:00:00
abstract::The present survey deals with the initial stage of the calcification process in bone and other hard tissues, with special reference to the organic-inorganic relationship and the transformation that the early inorganic particles undergo as the process moves towards completion. Electron microscope studies clearly exclud...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12074231
更新日期:2014-07-23 00:00:00
abstract::One new α-pyrone (nocapyrone R (1)), and three known γ-pyrones (nocapyrones B, H and L (2-4)) were isolated from the culture extract of a Nocardiopsis strain collected from marine sediment. Structures of these compounds were determined on the basis of spectroscopic data including NMR and MS. γ-Pyrones 2-4 were found t...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12074110
更新日期:2014-07-08 00:00:00
abstract::Two new indole-diterpenoids (1 and 2) and a new isocoumarin (3), along with the known β-aflatrem (4), paspalinine (5), leporin B (6), α-cyclopiazonic acid (7), iso-α-cyclopiazonic acid (8), ditryptophenaline (9), aflatoxin B1 (10), 7-O-acetylkojic acid (11) and kojic acid (12), were isolated from the fermentation brot...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12073970
更新日期:2014-06-30 00:00:00
abstract::Bis(2,3-dibromo-4,5-dihydroxybenzyl) ether (BDDE) is a bromophenol isolated from marine algae. Previous reports have shown that BDDE possesses cytotoxic and antibacterial activity. In the present study, we demonstrate that BDDE displays broad-spectrum antifungal activities, especially on Botrytis cinerea. BDDE inhibit...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12073838
更新日期:2014-06-27 00:00:00
abstract::Cyclic imines are lipophilic marine toxins that bioaccumulate in seafood. Their structure comprises a cyclic-imino moiety, responsible for acute neurotoxicity in mice. Cyclic imines have not been linked yet to human poisonings and are not regulated in Europe, although the European Food Safety Authority requires more d...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12063706
更新日期:2014-06-23 00:00:00
abstract::With the depletion of global fish stocks, caused by high demand and effective fishing techniques, alternative sources for long chain omega-3 fatty acids are required for human nutrition and aquaculture feeds. Recent research has focused on land-based cultivation of microalgae, the primary producers of omega-3 fatty ac...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12063381
更新日期:2014-06-04 00:00:00
abstract::In recent years many sterols with unusual structures and promising biological profiles have been identified from marine sources. Here we report the isolation of a series of 24-alkylated-hydroxysteroids from the soft coral Sinularia kavarattiensis, acting as pregnane X receptor (PXR) modulators. Starting from this scaf...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12063091
更新日期:2014-05-27 00:00:00
abstract::In the last decades, research has focused on the capabilities of microbes to secrete exopolysaccharides (EPS), because these polymers differ from the commercial ones derived essentially from plants or algae in their numerous valuable qualities. These biopolymers have emerged as new polymeric materials with novel and u...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md12053005
更新日期:2014-05-22 00:00:00
abstract::The study of spatial distribution of secondary metabolites within microbial cells facilitates the screening of candidate strains from marine environments for functional metabolites and allows for the subsequent assessment of the production of metabolites, such as antibiotics. This paper demonstrates the first applicat...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12052827
更新日期:2014-05-13 00:00:00
abstract::One of the most distinctive and defining features of coleoid cephalopods-squid, cuttlefish and octopus-is their inking behavior. Their ink, which is blackened by melanin, but also contains other constituents, has been used by humans in various ways for millennia. This review summarizes our current knowledge of cephalo...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md12052700
更新日期:2014-05-12 00:00:00
abstract::Most giant groupers in the market are derived from inbred stock. Inbreeding can cause trait depression, compromising the animals' fitness and disease resistance, obligating farmers to apply increased amounts of drugs. In order to solve this problem, a pedigree classification method is needed. Here, microsatellite and ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12052397
更新日期:2014-04-30 00:00:00
abstract::Eighteen analogues of the marine cytotoxic linear peptide tasiamide were designed, synthesized and screened for their inhibitory activities against the growth of human nasopharyngeal carcinoma (KB) and human non-small cell lung tumor (A549) cell lines. The results indicated that minor modifications of the C-terminus w...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12042308
更新日期:2014-04-22 00:00:00
abstract::The structures, names, bioactivities and references of 138 briarane-type diterpenoids, including 87 new compounds, are summarized in this review. All the briarane-type compounds mentioned in this review article were obtained from gorgonian corals including the genus Briareum, Dichotella, Junceella and Verrucella. Some...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md12042164
更新日期:2014-04-10 00:00:00
abstract::Recently, the studies on the prevention and treatment of human papillomavirus (HPV) which is closely related to the cervical cancer and other genital diseases are attracting more and more attention all over the world. Marine-derived polysaccharides and other bioactive compounds have been shown to possess a variety of ...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md12042019
更新日期:2014-04-03 00:00:00
abstract::In our search for bioactive metabolites from marine organisms, we have investigated the polar fraction of the organic extract of the Red Sea sponge Theonella swinhoei. Successive chromatographic separations and final HPLC purification of the potent antifungal fraction afforded a new bicyclic glycopeptide, theonellamid...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12041911
更新日期:2014-04-01 00:00:00
abstract::Soft corals are common marine organisms that inhabit tropical and subtropical oceans. They are shown to be rich source of secondary metabolites with biological activities. In this work, soft corals from two geographical locations were investigated using ¹H-NMR spectroscopy coupled with multivariate statistical analysi...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12041876
更新日期:2014-03-28 00:00:00
abstract::Peridinin and fucoxanthin, which are natural carotenoids isolated from a symbiotic dinoflagellate, Symbiodinium sp., and a brown alga, Petalonia fascia, respectively, were compared for inhibitory effects on delayed-type hypersensitivity in mice. The number of eosinophils at the site of inflammation and in peripheral b...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12041773
更新日期:2014-03-27 00:00:00
abstract::Two new guaiazulene-based analogues, ochracenoids A (1) and B (2), along with four known analogues (3-6), were isolated from the gorgonian Anthogorgia ochracea collected from the South China Sea. The planar structures of the new compounds were elucidated by comprehensive spectroscopic data. The absolute configuration ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12031569
更新日期:2014-03-14 00:00:00
abstract::Numerous antimicrobial peptides (AMPs) from marine fish have been identified, isolated and characterized. These peptides act as host defense molecules that exert antimicrobial effects by targeting the lipopolysaccharide (LPS) of Gram-negative bacteria. The LPS-AMP interactions are driven by the biophysical properties ...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md12031471
更新日期:2014-03-13 00:00:00
abstract::A series of novel cyclic marinopyrroles were designed and synthesized. Their activity to disrupt the binding of the pro-apoptotic protein, Bim, to the pro-survival proteins, Mcl-1 and Bcl-x(L), was evaluated using ELISA assays. Both atropisomers of marinopyrrole A (1) show similar potency. A tetrabromo congener 9 is t...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12031335
更新日期:2014-03-07 00:00:00